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Engineering the stereochemistry of cephalosporin for specific detection of pathogenic carbapenemase-expressing bacteria. Angewandte Chemie (International ed. in English) Shi, H., Cheng, Y., Lee, K. H., Luo, R. F., Banaei, N., Rao, J. 2014; 53 (31): 8113-8116

Abstract

Reported herein is the design of fluorogenic probes specific for carbapenem-resistant Enterobacteriaceae (CRE) and they were designed based on stereochemically modified cephalosporin having a 6,7-trans configuration. Through experiments using recombinant ß-lactamase enzymes and live bacterial species, these probes demonstrate the potential for use in the specific detection of carbapenemases, including metallo-ß-lactamases in active bacterial pathogens.

View details for DOI 10.1002/anie.201402012

View details for PubMedID 24764125