Measuring the severity of topical 5-Fluorouracil toxicity. Journal of cutaneous medicine and surgery Korgavkar, K., Firoz, E. F., Xiong, M., Lew, R., Marcolivio, K., Burnside, N., Dyer, R., Weinstock, M. A. 2014; 18 (4): 229-235


Topical 5% 5-fluorouracil (5-FU) is known to cause toxicity, such as erythema, pain, and crusting/erosions.We sought to develop a scale to measure this toxicity and test the scale for reliability.A scale was developed involving four parameters: erythema severity, percentage of face involved in erythema, crusting/erosions severity, and percentage of face involved in crusting/erosions. Thirteen raters graded 99 sets of photographs from the Veterans Affairs Keratinocyte Carcinoma Chemoprevention (VAKCC) Trial using these parameters.Intraclass correlation overall for 13 raters was 0.82 (95% CI 0.77-0.86). There was no statistically significant trend in reliability by level of training in dermatology.This scale is a reliable method of evaluating the severity of toxicity from topical 5-fluorouracil and can be used by dermatologists and nondermatologists alike.

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