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The role of cyclic-AMP binding protein (CREB) in leukemia cell proliferation and acute leukemias LEUKEMIA & LYMPHOMA Shankar, D. B., Sakamoto, K. M. 2004; 45 (2): 265-270

Abstract

Leukemia is a result of accumulating genetic alterations. The collaboration of mutations that offer survival and proliferative signals, together with mutations that result in lack of differentiation, is thought to cause a leukemic phenotype. The cyclic-AMP Response Element Binding Protein (CREB) is a transcription factor that is known to be a downstream component of the GM-CSF and IL-3 signaling pathways. We previously showed that CREB is overexpressed in blast cells from patients with acute leukemias. In this paper, we review the role of CREB in hematopoiesis, cell proliferation and acute leukemias.

View details for DOI 10.1080/1042819031000151095

View details for Web of Science ID 000186393200007

View details for PubMedID 15101710