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Bone Morphogenetic Protein-2-Impregnated Biomimetic Scaffolds Successfully Induce Bone Healing in a Marginal Mandibular Defect LARYNGOSCOPE DeConde, A. S., Sidell, D., Lee, M., Bezouglaia, O., Low, K., Elashoff, D., Grogan, T., Tetradis, S., Aghaloo, T., St John, M. 2013; 123 (5): 1149-1155

Abstract

To test the osteoregenerative potential and dosing of bone morphogenetic protein-2 (BMP-2)-impregnated biomimetic scaffolds in a rat model of a mandibular defect.Prospective study using an animal model.Varied doses of BMP-2 (0.5, 1, 0.5, 0.5 in microspheres, 5, and 15 µg) were absorbed onto a biomimetic scaffold. Scaffolds were then implanted into marginal mandibular defects in rats. Blank scaffolds and unfilled defects were used as negative controls. Two months postoperatively, bone healing was analyzed with microcomputerized tomography (microCT).MicroCT analysis demonstrated that all doses of BMP-2 induced successful healing of marginal mandibular defects in a rat mandible. Increasing doses of BMP-2 on the scaffolds produced increased tissue healing, with 15 µg demonstrating significantly more healing than all other dosing (P < .01).BMP-2-impregnated biomimetic scaffolds successfully induce bone healing in a marginal mandibular defect in the rat. Percentage healing of defect, percentage of bone within healed tissue, and total bone volume are all a function of BMP-2 dosing. There appears to be an optimal dose of 5 µg beyond which there is no increase in bone volume.NA.

View details for DOI 10.1002/lary.23782

View details for Web of Science ID 000320782200018

View details for PubMedID 23553490