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Stanford Health Care

Galectin-1 links tumor hypoxia and radiotherapy. Glycobiology Kuo, P., Le, Q. 2014; 24 (10): 921-925

Abstract

Radiation therapy is a main stay in treating solid tumors and plays a significant role in definitive and adjuvant therapy. Unfortunately, local control remains a challenge, in which the success of radiotherapy is largely dictated by tumor hypoxia, DNA damage repair and the antitumor immune response. Extensive efforts have therefore been devoted to targeting the factors that attenuate tumor radiosensitivity, although with limited success. Mounting evidence suggests that tumor and endothelial cells may utilize galectin-1 (Gal-1) for protection against radiation through several mechanisms. Targeting Gal-1 in combination with radiotherapy provides an exciting approach to address several radiation-prohibitive mechanisms.

View details for DOI 10.1093/glycob/cwu062

View details for PubMedID 24973253

View details for PubMedCentralID PMC4153759