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Pulmonary hypertension in patients with advanced heart failure is associated with increased levels of interleukin-6 BIOMARKERS Dolenc, J., Sebestjen, M., Vrtovec, B., Kozelj, M., Haddad, F. 2014; 19 (5): 385-390

Abstract

Inflammatory, endothelial and neurohormonal biomarkers are involved in heart failure (HF) and pulmonary hypertension (PH) pathogenesis.To study these biomarkers in PH due to advanced HF.Thirty adults with HF were included. Interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a), high-sensitivity C-reactive protein (hsCRP), endothelin-1 and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) were measured in peripheral vein and pulmonary artery during right heart catheterisation.IL-6, TNF-a, hsCRP and NT-proBNP correlated with pulmonary pressures independent of ventricular function, HF etiology and vascular bed. IL-6 was independent predictor of systolic pulmonary artery pressure (sPAP).Inflammatory biomarkers correlate to PH severity. IL-6 predicts sPAP in advanced HF.

View details for DOI 10.3109/1354750X.2014.918654

View details for Web of Science ID 000340430100005

View details for PubMedID 24831174