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X-ray-Induced Shortwave Infrared Biomedical Imaging Using Rare-Earth Nanoprobes. Nano letters Naczynski, D. J., Sun, C., Türkcan, S., Jenkins, C., Koh, A. L., Ikeda, D., Pratx, G., Xing, L. 2015; 15 (1): 96-102

Abstract

Shortwave infrared (SWIR or NIR-II) light provides significant advantages for imaging biological structures due to reduced autofluorescence and photon scattering. Here, we report on the development of rare-earth nanoprobes that exhibit SWIR luminescence following X-ray irradiation. We demonstrate the ability of X-ray-induced SWIR luminescence (X-IR) to monitor biodistribution and map lymphatic drainage. Our results indicate X-IR imaging is a promising new modality for preclinical applications and has potential for dual-modality molecular disease imaging.

View details for DOI 10.1021/nl504123r

View details for PubMedID 25485705

View details for PubMedCentralID PMC4296927