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Taking T cell priming down a Notch: signaling through Notch receptors enhances T cell sensitivity to antigen. Immunity Thauland, T. J., Butte, M. J. 2015; 42 (1): 6-8
Abstract
Notch receptors are widely expressed and have recognized functions in thymocytes and mature T cells. In this issue, Laky et al. (2015) show that Notch interactions with Delta-like ligand 4 (DLL4) amplify priming of naive T cells.
View details for DOI 10.1016/j.immuni.2014.12.026
View details for PubMedID 25607451