Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Rhee, S. Y., Liu, T., Ravela, J., Gonzales, M. J., Shafer, R. W. 2004; 48 (8): 3122-3126


In a sample of 6,156 sequences from 4,183 persons, the top 30 patterns of protease inhibitor, nucleoside reverse transcriptase (RT) inhibitor, and nonnucleoside RT inhibitor mutations accounted for 55, 46, and 66%, respectively, of sequences with drug resistance mutations. Characterization of the phenotypic and clinical significance of these common patterns may lead to improved treatment recommendations for a large proportion of patients for whom antiretroviral therapy is failing.

View details for DOI 10.1128/AAC.48.8.3122-3126.2004

View details for Web of Science ID 000222998300049

View details for PubMedID 15273130

View details for PubMedCentralID PMC478552