Patterns of peripheral neuropathy in ART-na < ve patients initiating modern ART regimen JOURNAL OF NEUROVIROLOGY Lee, A. J., Bosch, R. J., Evans, S. R., Wu, K., Harrison, T., Grant, P., Clifford, D. B. 2015; 21 (2): 210-218


The purpose of this study was to evaluate associations of pre-ART CD4 with peripheral neuropathy (PN) and estimate the prevalence of PN in HIV-positive patients starting modern combination antiretroviral therapy (cART) regimens. ART-naïve subjects initiating cART were followed longitudinally and screened for signs/symptoms of PN. Lower pre-ART CD4 count was associated with post-ART PN. After 7 years (n?=?117), the prevalence (95 % CI) of PN and SPN were 31 % (23, 40 %) and 5 % (2, 11 %) with pre-ART CD4 count >250 copies/µL. PN continues to be identified in HIV-infected individuals on modern cART by targeted assessment but is generally without symptoms.

View details for DOI 10.1007/s13365-015-0327-1

View details for Web of Science ID 000351671300010

View details for PubMedID 25678143