Skip to main content
 
Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
Stanford Health Care

PLASMA PRORENIN IN 1ST-TRIMESTER PREGNANCY - RELATIONSHIP TO CHANGES IN HUMAN CHORIONIC-GONADOTROPIN

PLASMA PRORENIN IN 1ST-TRIMESTER PREGNANCY - RELATIONSHIP TO CHANGES IN HUMAN CHORIONIC-GONADOTROPIN AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY Sealey, J. E., McCord, D., TAUFIELD, P. A., ALES, K. A., Druzin, M. L., Atlas, S. A., Laragh, J. H. 1985; 153 (5): 514-519

Abstract

Prorenin and human chorionic gonadotropin are both synthesized in chorionic cells. The relationship of changes in maternal plasma prorenin to changes in human chorionic gonadotropin were therefore evaluated during the first trimester. In samples submitted to the routine chemistry laboratory for detection of pregnancy a positive relationship was observed between prorenin and beta human chorionic gonadotropin during the 5 weeks following conception. Subsequently human chorionic gonadotropin continued to rise but prorenin had reached a plateau. Serial studies in one subject demonstrated that prorenin had increased to 65% of maximum by the thirteenth day following conception whereas human chorionic gonadotropin had risen to only 0.2% of maximum. By 3 to 5 days post partum, beta human chorionic gonadotropin had fallen by 98% but prorenin had fallen by only 50%. The early rise in prorenin following conception and the relatively slow fall post partum suggest that pregnancy-related changes in maternal plasma prorenin are of maternal, not fetal, origin.

View details for Web of Science ID A1985AUC1400009

View details for PubMedID 3904454