INTERLEUKIN-3-DEPENDENT AND INTERLEUKIN-3-INDEPENDENT MAST-CELLS STIMULATED WITH IGE AND ANTIGEN EXPRESS MULTIPLE CYTOKINES JOURNAL OF EXPERIMENTAL MEDICINE Burd, P. R., ROGERS, H. W., Gordon, J. R., Martin, C. A., Jayaraman, S., Wilson, S. D., Dvorak, A. M., GALLI, S. J., Dorf, M. E. 1989; 170 (1): 245-257

Abstract

In response to IgE and specific multivalent antigen, mast cell lines (both growth factor-dependent and -independent) induce the transcription and/or secretion of a number of cytokines having a wide spectrum of activities. We have identified IL-1, IL-3, IL-5, IL-6, IFN-gamma, GM-CSF, JE, MIP1 alpha, MIP1 beta, and TCA3 RNA in at least two of four mast cell clones. The production of these products (except JE) is activation-associated and can be induced by IgE plus antigen. In selected instances cytokine expression can also be induced by activation with Con A or phorbol ester plus ionophore, albeit to levels less than those observed with IgE plus antigen. In addition, long-term mast cell clones and primary cultures of bone marrow-derived mast cells specifically release IL-1, IL-4, and/or IL-6 bioactivity after activation. These findings suggest that in addition to their inflammatory effector function mast cells may serve as a source of growth and regulatory factors. The relationship of mast cells to cells of the T lymphocyte lineage is discussed.

View details for Web of Science ID A1989AE68500018

View details for PubMedID 2473161