Transdermal Delivery of Functional Collagen Via Polyvinylpyrrolidone Microneedles ANNALS OF BIOMEDICAL ENGINEERING Sun, W., Inayathullah, M., Manoukian, M. A., Malkovskiy, A. V., Manickam, S., Marinkovich, M. P., Lane, A. T., Tayebi, L., Seifalian, A. M., Rajadas, J. 2015; 43 (12): 2978-2990


Collagen makes up a large proportion of the human body, particularly the skin. As the body ages, collagen content decreases, resulting in wrinkled skin and decreased wound healing capabilities. This paper presents a method of delivering type I collagen into porcine and human skin utilizing a polyvinylpyrrolidone microneedle delivery system. The microneedle patches were made with concentrations of 1, 2, 4, and 8% type I collagen (w/w). Microneedle structures and the distribution of collagen were characterized using scanning electron microscopy and confocal microscopy. Patches were then applied on the porcine and human skin, and their effectiveness was examined using fluorescence microscopy. The results illustrate that this microneedle delivery system is effective in delivering collagen I into the epidermis and dermis of porcine and human skin. Since the technique presented in this paper is quick, safe, effective and easy, it can be considered as a new collagen delivery method for cosmetic and therapeutic applications.

View details for DOI 10.1007/s10439-015-1353-0

View details for PubMedID 26066056