Fast and scalable inference of multi-sample cancer lineages. Genome biology Popic, V., Salari, R., Hajirasouliha, I., Kashef-Haghighi, D., West, R. B., Batzoglou, S. 2015; 16 (1): 91-?


Somatic variants can be used as lineage markers for the phylogenetic reconstruction of cancer evolution. Since somatic phylogenetics is complicated by sample heterogeneity, novel specialized tree-building methods are required for cancer phylogeny reconstruction. We present LICHeE (Lineage Inference for Cancer Heterogeneity and Evolution), a novel method that automates the phylogenetic inference of cancer progression from multiple somatic samples. LICHeE uses variant allele frequencies of somatic single nucleotide variants obtained by deep sequencing to reconstruct multi-sample cell lineage trees and infer the subclonal composition of the samples. LICHeE is open source and available at .

View details for DOI 10.1186/s13059-015-0647-8

View details for PubMedID 25944252

View details for PubMedCentralID PMC4501097