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Regulation of Helicobacter pylori Virulence Within the Context of Iron Deficiency JOURNAL OF INFECTIOUS DISEASES Noto, J. M., Lee, J. Y., Gaddy, J. A., Cover, T. L., Amieva, M. R., Peek, R. M. 2015; 211 (11): 1790-1794

Abstract

Helicobacter pylori strains that harbor the oncoprotein CagA increase gastric cancer risk, and this risk is augmented under iron-deficient conditions. We demonstrate here that iron depletion induces coccoid morphology in strains lacking cagA. To evaluate the stability of augmented H. pylori virulence phenotypes stimulated by low-iron conditions, H. pylori isolated from iron-depleted conditions in vivo were serially passaged in vitro. Long-term passage decreased the ability of hypervirulent strains to translocate CagA or induce interleukin 8, indicating that hypervirulent phenotypes stimulated by low-level iron conditions are reversible. Therefore, rectifying iron deficiency may attenuate disease among H. pylori-infected persons with no response to antibiotics.

View details for DOI 10.1093/infdis/jiu805

View details for Web of Science ID 000355675100013

View details for PubMedID 25505301

View details for PubMedCentralID PMC4447831