TOWARD A BIOCHEMICAL CLASSIFICATION OF DEPRESSIVE DISORDERS-IX - DST RESULTS AND PLATELET MAO ACTIVITY BRITISH JOURNAL OF PSYCHIATRY Schatzberg, A. F., Rothschild, A. J., Gerson, B., LERBINGER, J. E., Schildkraut, J. J. 1985; 146 (JUN): 633-637

Abstract

Post-dexamethasone cortisol and platelet monoamine oxidase (MAO) activity levels were examined in 50 depressed patients. The incidence of non-suppression was significantly greater in patients with high platelet MAO activity than in those with low activity. Similar results were obtained when males and females were analysed separately. The mean 4 p.m. post-dexamethasone cortisol level was significantly higher in those patients who had high MAO activity than in their low MAO counterparts. Moreover, a statistically significant positive correlation was observed between platelet MAO activity and 4 p.m. post-dexamethasone cortisol levels.

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View details for PubMedID 4016477