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Abstract
To assess the early therapeutic effects of anti-EMMPRIN (extracellular matrix metalloprotease inducer) antibody with/without cisplatin or X-ray radiation in head and neck cancer mouse models using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).Mice bearing SCC1 (or OSC19) tumor xenografts were treated with anti-EMMPRIN antibody, radiation, cisplatin, or anti-EMMPRIN antibody plus cisplatin (or radiation) for a week (n?=?4-5 per group). DCE-MRI was carried out on a 9.4T small animal MR scanner on days 0, 3, and 7, and K(trans) values were averaged in a 0.5-mm-thick peripheral tumor region. Ki67 and CD31 staining were implemented for all tumors after imaging.The K(trans) changes of SCC1 and OSC19 tumors treated with anti-EMMPRIN antibody for 3 days were -18?±?8% and 4?±?7%, respectively, which were significantly lower than those of control groups (39?±?5% and 45?±?7%; P?=?0.0025 and 0.0220, respectively). When cisplatin was added, those were -42?±?9% and -44?±?9%, respectively, and with radiation, -45?±?9% and -27?±?10%, respectively, which were also significantly lower than those of control groups (P?
View details for DOI 10.1002/jmri.24871
View details for PubMedID 25704985
View details for PubMedCentralID PMC4545484