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Circulating Tumor Cells and Circulating Tumor DNA: Challenges and Opportunities on the Path to Clinical Utility CLINICAL CANCER RESEARCH Ignatiadis, M., Lee, M., Jeffrey, S. S. 2015; 21 (21): 4786-4800

Abstract

Recent technological advances have enabled the detection and detailed characterization of circulating tumor cells (CTC) and circulating tumor DNA (ctDNA) in blood samples from patients with cancer. Often referred to as a "liquid biopsy," CTCs and ctDNA are expected to provide real-time monitoring of tumor evolution and therapeutic efficacy, with the potential for improved cancer diagnosis and treatment. In this review, we focus on these opportunities as well as the challenges that should be addressed so that these tools may eventually be implemented into routine clinical care. Clin Cancer Res; 21(21); 4786-800. ©2015 AACR.

View details for DOI 10.1158/1078-0432.CCR-14-1190

View details for Web of Science ID 000364488100009

View details for PubMedID 26527805