Abstract

Perioperative ß-blocker strategies are important to reduce risks of adverse events. Effectiveness and safety may differ according to patients' baseline risk.To determine the risk of major adverse cardiovascular events (MACEs) associated with long-term ß-blocker therapy in patients with uncomplicated hypertension undergoing noncardiac surgery.Association study based on in-hospital records and out-of-hospital pharmacotherapy use using a Danish nationwide cohort of patients with uncomplicated hypertension treated with at least 2 antihypertensive drugs (ß-blockers, thiazides, calcium antagonists, or renin-angiotensin system [RAS] inhibitors) undergoing noncardiac surgery between 2005 and 2011.Various antihypertensive treatment regimens, chosen as part of usual care.Thirty-day risk of MACEs?(cardiovascular death, nonfatal ischemic stroke, nonfatal myocardial infarction) and all-cause mortality, assessed using multivariable logistic regression models and adjusted numbers needed to harm (NNH).The baseline characteristics of the 14,644 patients who received ß-blockers (65% female, mean [SD] age, 66.1 [12.0] years) were similar to those of the 40,676 patients who received other antihypertensive drugs (57% female, mean [SD] age, 65.9 [11.8] years). Thirty-day MACEs occurred in 1.3% of patients treated with ß-blockers compared with 0.8% of patients not treated with ß-blockers (P?

View details for DOI 10.1001/jamainternmed.2015.5346

View details for Web of Science ID 000366332000011

View details for PubMedID 26436291