Deep brain stimulation (DBS) at the interface of neurology and psychiatry JOURNAL OF CLINICAL INVESTIGATION Williams, N. R., Okun, M. S. 2013; 123 (11): 4546-4556


Deep brain stimulation (DBS) is an emerging interventional therapy for well-screened patients with specific treatment-resistant neuropsychiatric diseases. Some neuropsychiatric conditions, such as Parkinson disease, have available and reasonable guideline and efficacy data, while other conditions, such as major depressive disorder and Tourette syndrome, have more limited, but promising results. This review summarizes both the efficacy and the neuroanatomical targets for DBS in four common neuropsychiatric conditions: Parkinson disease, Tourette syndrome, major depressive disorder, and obsessive-compulsive disorder. Based on emerging new research, we summarize novel approaches to optimization of stimulation for each neuropsychiatric disease and we review the potential positive and negative effects that may be observed following DBS. Finally, we summarize the likely future innovations in the field of electrical neural-network modulation.

View details for DOI 10.1172/JCI68341

View details for Web of Science ID 000326611900002

View details for PubMedID 24177464

View details for PubMedCentralID PMC3809784