Adjunctive Valproic Acid in Management-Refractory Hyperactive Delirium: A Case Series and Rationale. journal of neuropsychiatry and clinical neurosciences Sher, Y., Miller, A. C., Lolak, S., Ament, A., Maldonado, J. R. 2015; 27 (4): 365-370


Patients with delirium may fail to respond to standard therapies. Sixteen patients with management-refractory hyperactive delirium responded to adjunctive valproic acid, with complete resolution of hyperactive delirium in 13 cases. A rationale for using valproic acid in such circumstances is discussed.

View details for DOI 10.1176/appi.neuropsych.14080190

View details for PubMedID 25803136