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Effect of long-term antibiotic use on weight in adolescents with acne. journal of antimicrobial chemotherapy Contopoulos-Ioannidis, D. G., Ley, C., Wang, W., Ma, T., Olson, C., Shi, X., Luft, H. S., Hastie, T., Parsonnet, J. 2016; 71 (4): 1098-1105

Abstract

Antibiotics increase weight in farm animals and may cause weight gain in humans. We used electronic health records from a large primary care organization to determine the effect of antibiotics on weight and BMI in healthy adolescents with acne.We performed a retrospective cohort study of adolescents with acne prescribed =4 weeks of oral antibiotics with weight measurements within 18 months pre-antibiotics and 12 months post-antibiotics. We compared within-individual changes in weight-for-age Z-scores (WAZs) and BMI-for-age Z-scores (BMIZs). We used: (i) paired t-tests to analyse changes between the last pre-antibiotics versus the first post-antibiotic measurements; (ii) piecewise-constant-mixed models to capture changes between mean measurements pre- versus post-antibiotics; (iii) piecewise-linear-mixed models to capture changes in trajectory slopes pre- versus post-antibiotics; and (iv) ?(2) tests to compare proportions of adolescents with =0.2 Z-scores WAZ or BMIZ increase or decrease.Our cohort included 1012 adolescents with WAZs; 542 also had BMIZs. WAZs decreased post-antibiotics in all analyses [change between last WAZ pre-antibiotics versus first WAZ post-antibiotics?=?-0.041 Z-scores (P?

View details for DOI 10.1093/jac/dkv455

View details for PubMedID 26782773

View details for PubMedCentralID PMC4790625