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OPPOSITE EFFECTS OF TOTAL LYMPHOID IRRADIATION ON T-CELL-DEPENDENT AND T-CELL-INDEPENDENT ANTIBODY-RESPONSES JOURNAL OF IMMUNOLOGY Tanay, A., Strober, S. 1984; 132 (2): 979-984

Abstract

The effect of total lymphoid irradiation (TLI) on the primary antibody response to the dinitrophenylated heterologous protein, keyhole limpet hemocyanin (DNP-KLH), in complete Freund's adjuvant (CFA), and to the trinitrophenylated polysaccharide antigen, Brucella abortus (TNP-BA), was studied in BALB/c mice. The antibody response to both antigens was diminished in comparison with nonirradiated mice when antigens were injected within 3 days after TLI. When the mice were immunized 30 days after completion of TLI the antibody response to DNP-KLH in CFA was still diminished, but the antibody response to TNP-BA was enhanced 5- to 10-fold as compared with that of control animals. The opposite effect of TLI on the two antibody responses was also observed in a syngeneic primary adoptive transfer system.

View details for Web of Science ID A1984SA08700075

View details for PubMedID 6361136