Beta-2 adrenoceptor genotype and progress in term and late preterm active labor AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY Miller, R. S., Smiley, R. M., Daniel, D., Weng, C., Emala, C. W., Blouin, J., Flood, P. D. 2011; 205 (2)


We sought to evaluate whether beta-2 adrenoceptor (ß2AR) genotype at a functional polymorphic site encoding for amino acid residue 16 influences rate of cervical dilatation in term and late preterm active labor.Subjects who underwent vaginal delivery at =34 weeks' gestational age from May 2006 through August 2007 were identified. Each subject had provided venous blood from which DNA was extracted for ß2AR genotyping. Digital cervical examinations with paired examination times were collected from intrapartum records. Rate of cervical dilatation in active labor was determined using linear regression. Rates were compared between genotype groups.Among 401 subjects with satisfactory genotype and intrapartum data, overall rate of active labor was 0.76±0.01 cm/h. When labor was compared by genotype, homozygous Arg/Arg16 subjects progressed at a slower rate (0.64±0.03 cm/h) than all other pooled genotypes (0.8±0.02 cm/h, P<.001).Homozygous ß2AR genotype encoding for Arg/Arg16 was associated with slower progress in active labor.

View details for DOI 10.1016/j.ajog.2011.03.045

View details for Web of Science ID 000293219400028

View details for PubMedID 21600547

View details for PubMedCentralID PMC3192244