Clinical Use of Deferoxamine in Distraction Osteogenesis of Irradiated Bone JOURNAL OF CRANIOFACIAL SURGERY Momeni, A., Rapp, S., Donneys, A., Buchman, S. R., Wan, D. C. 2016; 27 (4): 880-882

Abstract

The deleterious effects of radiotherapy, including hypovascularity and hypocellularity, have made distraction of irradiated bones challenging. Animal studies, however, have demonstrated adjunctive measures such as the administration of deferoxamine to significantly improve bone regeneration across irradiated distraction gaps. In this report, the authors demonstrate, for the first time, enhanced bone formation following deferoxamine application in a patient following distraction of a previously irradiated maxilla. Computed tomography imaging of the pterygomaxillary buttress on the side of administration revealed significantly increased bone area and density relative to the contralateral buttress. This is the first presentation of clinical deferoxamine use to promote bone formation following irradiated bone distraction and highlights the promise for this adjunctive measure to make outcomes after distraction of irradiated bone more reliable.

View details for DOI 10.1097/SCS.0000000000002633

View details for Web of Science ID 000378088800052

View details for PubMedID 27171947