Increased pericardial adipose tissue is correlated with atrial fibrillation and left atrial dilatation CLINICAL RESEARCH IN CARDIOLOGY Greif, M., von Ziegler, F., Wakili, R., Tittus, J., Becker, C., Helbig, S., Laubender, R. P., Schwarz, W., D'Anastasi, M., Schenzle, J., Leber, A. W., Becker, A. 2013; 102 (8): 555-562


Pericardial adipose tissue (PAT), a visceral fat depot surrounding the heart, serves as an endocrine active organ and is associated with inflammation. There is growing evidence that atrial fibrillation (AF) is linked with inflammation, which in turn can be a promoter of left atrial remodeling. The aim of this study was to evaluate a potential correlation of PAT to AF and left atrial structural remodeling represented by LA size.PAT was measured in 1,288 patients who underwent coronary artery calcium-scanning for coronary risk stratification. LA size was determined by two independent readers. Patients were subdivided into patients without AF, patients with paroxysmal and persistent AF.PAT was independently correlated with AF, persistent AF, and LA size (all p values <0.001). No association could be observed between paroxysmal AF and PAT. These associations persisted after multivariate adjustment for AF risk factors such as age, hypertension, valvular disease, heart failure, and body mass index (AF: OR 1.52, 95 % CI 1.15-2.00, p = 0.003; persistent AF: OR 2.58, 95 % CI 1.69-3.99, p = 0.001; LA size: regression coefficient 0.15 with 95 % CI 0.10-0.20, p < 0.001).PAT is associated with AF, in particular with persistent AF and LA size. These findings suggest that PAT could be an independent risk factor for the development of AF and for LA remodeling.

View details for DOI 10.1007/s00392-013-0566-1

View details for Web of Science ID 000321965200002

View details for PubMedID 23584714