Pathophysiology of contrast-induced nephropathy AMERICAN JOURNAL OF CARDIOLOGY Tumlin, J., Stacul, F., Adam, A., Becker, C. R., Davidson, C., Lameire, N., McCullough, P. A. 2006; 98 (6A): 14K-20K


Contrast-induced nephropathy (CIN) is the third leading cause of acute kidney injury in hospitalized patients and is associated with significant patient morbidity. The pathogenesis of CIN is complex and not fully understood, but iodinated contrast agents induce intense and prolonged vasoconstriction at the corticomedullary junction of the kidney. Moreover, high-osmolar dyes directly impair the autoregulatory capacity of the kidney through a loss of nitric oxide production. These effects, coupled with direct tubular toxicity of contrast media, lead to overt acute tubular necrosis and the syndrome of CIN.

View details for DOI 10.1016/j.amjcard.2006.01.020

View details for Web of Science ID 000240840300004

View details for PubMedID 16949376