Effect of Fluid Status at Week 12 on Visual and Anatomic Outcomes at Week 52 in the VIEW 1 and 2 Trials OPHTHALMIC SURGERY LASERS & IMAGING RETINA Moshfeghi, D. M., Hariprasad, S. M., Marx, J. L., Thompson, D., Soo, Y., Gibson, A., Saroj, N., Vitti, R., Heier, J. S. 2016; 47 (3): 238-244


To evaluate effect of retinal fluid status at week 12 on visual and anatomic outcomes at week 52 in patients with neovascular age-related macular degeneration from the VIEW studies.Post-hoc analysis included 1,465 eyes treated with intravitreal aflibercept (Eylea; Regeneron, Tarrytown, NY) 2 mg every 4 weeks (2q4) or every 8 weeks following three initial monthly injections (2q8) or ranibizumab (Lucentis; Genentech, South San Francisco, CA) 0.5 mg every 4 weeks (Rq4), which had known retinal fluid status at weeks 12 and 52.At 12 weeks, 512 (35%) eyes had fluid and 953 (65%) were fluid-free. Two hundred three (41.5%), 148 (29.8%), and 161 (33.5%) eyes had fluid in Rq4, 2q4, and 2q8, respectively. Best-corrected visual acuity (BCVA) change at week 52 from baseline was independent of retinal fluid status at week 12 or treatment assignment. Eyes were more likely to remain fluid-free at week 52 if absent of fluid at week 12.At week 52, 2q4, 2q8, and Rq4 improved BCVA independent of fluid status at week 12.

View details for DOI 10.3928/23258160-20160229-06

View details for Web of Science ID 000378844900007

View details for PubMedID 26985797