BRCA1: a movement toward cancer prevention. Molecular & cellular oncology Alli, E., Ford, J. M. 2015; 2 (3)


Breast cancer susceptibility gene 1 (BRCA1) was first identified in 1994 and has since been shown to encode a tumor suppressor protein that maintains genetic stability through DNA damage response pathways. Carriers of mutations in BRCA1 are predisposed to breast and ovarian cancer; however, their cancers lack the targets for existing anticancer drugs. We describe a novel chemoprevention approach that uses DNA repair-activating agents to enhance the repair of oxidative DNA damage and, in turn, prevent tumorigenesis in the presence of mutant BRCA1.

View details for DOI 10.4161/23723556.2014.979685

View details for PubMedID 27308455