The role of stem cells in limb regeneration ORGANOGENESIS Zielins, E. R., Ransom, R. C., Leavitt, T. E., Longaker, M. T., Wan, D. C. 2016; 12 (1): 16-27


Limb regeneration is a complex yet fascinating process observed to some extent in many animal species, though seen in its entirety in urodele amphibians. Accomplished by formation of a morphologically uniform intermediate, the blastema, scientists have long attempted to define the cellular constituents that enable regrowth of a functional appendage. Today, we know that the blastema consists of a variety of multipotent progenitor cells originating from a variety of tissues, and which contribute to limb tissue regeneration in a lineage-restricted manner. By continuing to dissect the role of stem cells in limb regeneration, we can hope to one day modulate the human response to limb amputation and facilitate regrowth of a working replacement.

View details for DOI 10.1080/15476278.2016.1163463

View details for Web of Science ID 000377930900002

View details for PubMedID 27008101

View details for PubMedCentralID PMC4882123