Burning Fat Fuels Leukemic Stem Cell Heterogeneity. Cell stem cell Thomas, D., Majeti, R. 2016; 19 (1): 1-2


Obese leukemia patients exhibit reduced survival after chemotherapy, suggesting an important role of adipose tissue in disease progression. In this issue of Cell Stem Cell, Ye et al. (2016) reveal metabolic heterogeneity in leukemic stem cell (LSC) subpopulations and show that chemotherapy-resistant CD36+ LSCs co-opt gonadal adipose tissue to support their metabolism and survival.

View details for DOI 10.1016/j.stem.2016.06.014

View details for PubMedID 27392217