Infection Rates among Acute Leukemia Patients Receiving Alternative Donor Hematopoietic Cell Transplantation. Biology of blood and marrow transplantation Ballen, K., Woo Ahn, K., Chen, M., Abdel-Azim, H., Ahmed, I., Aljurf, M., Antin, J., Bhatt, A. S., Boeckh, M., Chen, G., Dandoy, C., George, B., Laughlin, M. J., Lazarus, H. M., MacMillan, M. L., Margolis, D. A., Marks, D. I., Norkin, M., Rosenthal, J., Saad, A., Savani, B., Schouten, H. C., Storek, J., Szabolcs, P., Ustun, C., Verneris, M. R., Waller, E. K., Weisdorf, D. J., Williams, K. M., Wingard, J. R., Wirk, B., Wolfs, T., Young, J. H., Auletta, J., Komanduri, K. V., Lindemans, C., Riches, M. L. 2016; 22 (9): 1636-1645

Abstract

Alternative graft sources (umbilical cord blood [UCB], matched unrelated donors [MUD], or mismatched unrelated donors [MMUD]) enable patients without a matched sibling donor to receive potentially curative hematopoietic cell transplantation (HCT). Retrospective studies demonstrate comparable outcomes among different graft sources. However, the risk and types of infections have not been compared among graft sources. Such information may influence the choice of a particular graft source. We compared the incidence of bacterial, viral, and fungal infections in 1781 adults with acute leukemia who received alternative donor HCT (UCB, n=?568; MUD, n?=?930; MMUD, n?=?283) between 2008 and 2011. The incidences of bacterial infection at 1 year were 72%, 59%, and 65% (P?

View details for DOI 10.1016/j.bbmt.2016.06.012

View details for PubMedID 27343716