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Synthesis, structure-activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Han, X. J., Michne, J. A., Pin, S. S., Burris, K. D., Balanda, L. A., Fung, L. K., Fiedler, T., Browman, K. E., Taber, M. T., Zhang, J., Dubowchik, G. M. 2005; 15 (17): 3870-3873
Abstract
7-Aryl-6,7-dihydroimidazoimidazoles represent a novel series of high-affinity corticotropin-releasing factor 1 receptor antagonists. Here, we report their synthesis and SAR as well as behavioral activity of two exemplary compounds, 7b and 7k, in a mouse canopy model of anxiety.
View details for DOI 10.1016/j.bmcl.2005.05.117
View details for Web of Science ID 000231186000012
View details for PubMedID 15990298