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Preoperative risk factors for postoperative Clostridium difficile infection in colectomy patients AMERICAN JOURNAL OF SURGERY Krapohl, G. L., Morris, A. M., Cai, S., Englesbe, M. J., Aronoff, D. M., Campbell, D. A., Hendren, S. 2013; 205 (3): 343-347

Abstract

Wide variation among hospitals in the rate of Clostridium difficile infection (CDI) after surgery was hypothesized to be related to different prophylactic antibiotic practices.Between March 2008 and March 2010, 30-day confirmed postoperative CDI rates were prospectively collected for patients undergoing colectomy surgery at 23 hospitals participating in a collaborative quality improvement program. Preoperative variables significantly associated with CDI (P = .10) in a bivariate analysis were incorporated into a logistic regression model to test for independent associations.Among 4,936 patients, the overall rate of CDI was 1.6% (range by hospital, 0%-9%). After adjusting for patient comorbidities and hospital site, type of preoperative antibiotics used for prophylaxis was not significantly associated with CDI. Emergency surgery, low albumin, and neurologic and renal comorbidities emerged as independent preoperative predictors of CDI.Perioperative antibiotic practices did not prove to be independently associated with CDI after colectomy surgery.

View details for DOI 10.1016/j.amjsurg.2012.10.028

View details for Web of Science ID 000315948900043

View details for PubMedID 23375705

View details for PubMedCentralID PMC4119815