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Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels HUMAN MOLECULAR GENETICS Spracklen, C. N., Chen, P., Kim, Y. J., Wang, X., Cai, H., Li, S., Long, J., Wu, Y., Wang, Y. X., Takeuchi, F., Wu, J., Jung, K., Hu, C., Akiyama, K., Zhang, Y., Moon, S., Johnson, T. A., Li, H., Dorajoo, R., He, M., Cannon, M. E., Roman, T. S., Salfati, E., Lin, K., Guo, X., Sheu, W. H., Absher, D., Adair, L. S., Assimes, T. L., Aung, T., Cai, Q., Chang, L., Chen, C., Chien, L., Chuang, L., Chuang, S., Du, S., Fan, Q., Fann, C. S., Feranil, A. B., Friedlander, Y., Gordon-Larsen, P., Gu, D., Gui, L., Guo, Z., Heng, C., Hixson, J., Hou, X., Hsiung, C. A., Hu, Y., Hwang, M. Y., Hwu, C., Isono, M., Juang, J. J., Khor, C., Kim, Y. K., Koh, W., Kubo, M., Lee, I., Lee, S., Lee, W., Liang, K., Lim, B., Lim, S., Liu, J., Nabika, T., Pan, W., Peng, H., Quertermous, T., Sabanayagam, C., Sandow, K., Shi, J., Sun, L., Tan, P. C., Tan, S., Taylor, K. D., Teo, Y., Toh, S., Tsunoda, T., van Dam, R. M., Wang, A., Wang, F., Wang, J., Wei, W. B., Xiang, Y., Yao, J., Yuan, J., Zhang, R., Zhao, W., Chen, Y. I., Rich, S. S., Rotter, J. I., Wang, T., Wu, T., Lin, X., Han, B., Tanaka, T., Cho, Y. S., Katsuya, T., Jia, W., Jee, S., Chen, Y., Kato, N., Jonas, J. B., Cheng, C., Shu, X., He, J., Zheng, W., Wong, T., Huang, W., Kim, B., Tai, E., Mohlke, K. L., Sim, X. 2017; 26 (9): 1770-1784

Abstract

Large-scale meta-analyses of genome-wide association studies (GWAS) have identified?>175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). With differences in linkage disequilibrium (LD) structure and allele frequencies between ancestry groups, studies in additional large samples may detect new associations. We conducted staged GWAS meta-analyses in up to 69,414 East Asian individuals from 24 studies with participants from Japan, the Philippines, Korea, China, Singapore, and Taiwan. These meta-analyses identified (P?

View details for DOI 10.1093/hmg/ddx062

View details for Web of Science ID 000400912200015

View details for PubMedID 28334899