Soil Primes the Seed: Epigenetic Landscape Drives Tumor Behavior. Cell stem cell Whitson, R. J., Oro, A. E. 2017; 20 (2): 149-150


Whether invasive tumor phenotypes like EMT arise from oncogenic drivers or from priming of the pre-tumor cell of origin remains unknown. In this issue of Cell Stem Cell, Latil et al. (2017) show that the pre-tumor niche establishes a chromatin state predisposing squamous cell carcinomas to undergo EMT and metastasis, suggesting that the pre-tumor epigenome has prognostic value.

View details for DOI 10.1016/j.stem.2017.01.007

View details for PubMedID 28157493