NUSAP1 promotes invasion and metastasis of prostate cancer ONCOTARGET Gordon, C. A., Gong, X., Ganesh, D., Brooks, J. D. 2017; 8 (18): 29935-29950


We have previously identified nucleolar and spindle associated protein 1 (NUSAP1) as a prognostic biomarker in early stage prostate cancer. To better understand the role of NUSAP1 in prostate cancer progression, we tested the effects of increased and decreased NUSAP1 expression in cell lines, in vivo models, and patient samples. NUSAP1 promotes invasion, migration, and metastasis, possibly by modulating family with sequence similarity 101 member B (FAM101B), a transforming growth factor beta 1 (TGFß1) signaling effector involved in the epithelial to mesenchymal transition. Our findings provide insights into the importance of NUSAP1 in prostate cancer progression and provide a rationale for further study of NUSAP1 function, regulation, and clinical utility.

View details for DOI 10.18632/oncotarget.15604

View details for Web of Science ID 000400456200032

View details for PubMedID 28404898