Aspirin-Exacerbated Respiratory Disease OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA Walgama, E. S., Hwang, P. H. 2017; 50 (1): 83-?


Aspirin-exacerbated respiratory disease (AERD) is characterized by the triad of asthma, sinonasal polyposis, and aspirin intolerance. The hallmark of the disease is baseline overproduction of cysteinyl leukotrienes via the 5-lipoxygenase pathway, exacerbated by ingestion of aspirin. Patients with AERD have high rates of recidivistic polyposis following sinus surgery, although the improvement in quality of life following surgery is similar to aspirin-tolerant patients. The diagnosis is secured by a positive aspirin provocation test, usually administered by a medical allergist. Aspirin therapy is a unique treatment consideration for patients with AERD.

View details for DOI 10.1016/j.otc.2016.08.007

View details for Web of Science ID 000390983700008

View details for PubMedID 27888917