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CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero. Open forum infectious diseases Prahl, M., Jagannathan, P., McIntyre, T. I., Auma, A., Wamala, S., Nalubega, M., Musinguzi, K., Naluwu, K., Sikyoma, E., Budker, R., Odorizzi, P., Kakuru, A., Havlir, D. V., Kamya, M. R., Dorsey, G., Feeney, M. E. 2017; 4 (1): ofx022-?

Abstract

Sex differences in the immune response and in infectious disease susceptibility have been well described, although the mechanisms underlying these differences remain incompletely understood. We evaluated the frequency of cord blood CD4 T cell subsets in a highly malaria-exposed birth cohort of mother-infant pairs in Uganda by sex. We found that frequencies of cord blood regulatory T cell ([Treg] CD4(+)CD25(+)FoxP3(+)CD127(lo/-)) differed by infant sex, with significantly lower frequencies of Tregs in female than in male neonates (P = .006). When stratified by in utero malaria exposure status, this difference was observed in the exposed, but not in the unexposed infants.

View details for DOI 10.1093/ofid/ofx022

View details for PubMedID 28480292

View details for PubMedCentralID PMC5414097