The Roles of Immunity in the Prevention and Evolution of Pulmonary Arterial Hypertension AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Nicolls, M. R., Voelkel, N. F. 2017; 195 (10): 1292-1299

Abstract

This Perspective provides an in depth overview of the many aspects of inflammation which are associated with many forms of severe pulmonary hypertension.Details of the pathobiology of severe pulmonary hypertension are discussed in the context of the multicellular inflammatory vascular infiltrates which represent a lung vessel response to injury and and a localized immune response.The important question whether inflammation is cause or consequence of pulmonary hypertension should not distract from designing and conducting clinical pilot studies which examine the efficacy of existing immune system modulating drugs.

View details for DOI 10.1164/rccm.201608-1630PP

View details for Web of Science ID 000401501400008