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Fast Comprehensive Single-Sequence Four-Dimensional Pediatric Knee MRI With T-2 Shuffling JOURNAL OF MAGNETIC RESONANCE IMAGING Bao, S., Tamir, J. I., Young, J. L., Tariq, U., Uecker, M., Lai, P., Chen, W., Lustig, M., Vasanawala, S. S. 2017; 45 (6): 1700-1711


To develop and clinically evaluate a pediatric knee magnetic resonance imaging (MRI) technique based on volumetric fast spin-echo (3DFSE) and compare its diagnostic performance, image quality, and imaging time to that of a conventional 2D protocol.A 3DFSE sequence was modified and combined with a compressed sensing-based reconstruction resolving multiple image contrasts, a technique termed T2 Shuffling (T2 Sh). With Institutional Review Board (IRB) approval, 28 consecutive children referred for 3T knee MRI prospectively underwent a standard clinical knee protocol followed by T2 Sh. T2 Sh performance was assessed by two readers blinded to diagnostic reports. Interpretive discrepancies were resolved by medical record chart review and consensus between the readers and an orthopedic surgeon. Image quality was evaluated by rating anatomic delineation, with 95% confidence interval. A Wilcoxon rank-sum test assessed the null hypothesis that T2 Sh structure delineation compared to conventional 2D is unchanged. Intraclass correlation coefficients were calculated for interobserver agreement. Imaging time of the conventional protocol and T2 Sh was compared.There was 81% and 87% concordance between T2 Sh reports and diagnostic reports, respectively, for each reader. Upon consensus review, T2 Sh had 93% sensitivity and 100% specificity compared to clinical reports for detection of clinically relevant findings. The 95% confidence interval of diagnostic or better rating was 95-100%, with 34-80% interobserver agreement. There was no significant difference in structure delineation between T2 Sh and 2D, except for the retinaculum (P < 0.05), where 2D was preferred. Typical imaging time for T2 Sh and the conventional exam was 7 and 13 minutes, respectively.A single-sequence pediatric knee exam is feasible with T2 Sh, providing multiplanar, reformattable 4D images. Level of Evidence 2 J. Magn. Reson. Imaging 2016;00:000-000.

View details for DOI 10.1002/jmri.25508

View details for Web of Science ID 000401259900015