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Coding and noncoding genomic regions of Entamoeba histolytica have significantly different rates of sequence polymorphisms: Implications for epidemiological studies JOURNAL OF CLINICAL MICROBIOLOGY Bhattacharya, D., Haque, R., Singh, U. 2005; 43 (9): 4815-4819

Abstract

To evaluate genetic variability among Entamoeba histolytica strains, we sequenced 9,077 bp from each of 14 isolates. The polymorphism rates from coding and noncoding regions were significantly different (0.07% and 0.37%, respectively), indicating that these regions are subject to different selection pressures. Additionally, single nucleotide polymorphisms (SNPs) potentially associated with specific clinical outcomes were identified.

View details for DOI 10.1128/JCM.43.9.4815-4819.2005

View details for Web of Science ID 000232020400078

View details for PubMedID 16145147

View details for PubMedCentralID PMC1234137