Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
 

See our updated masking policy »

Stanford Health Care

Survival after resection of perihilar cholangiocarcinoma in patients with lymph node metastases. HPB Buettner, S., van Vugt, J. L., Gaspersz, M. P., Coelen, R. J., Roos, E., Labeur, T. A., Margonis, G. A., Ethun, C. G., Maithel, S. K., Poultsides, G., Tran, T., Idrees, K., Isom, C. A., Fields, R. C., Krasnick, B. A., Weber, S. M., Salem, A., Martin, R. C., Scoggins, C. R., Shen, P., Mogal, H. D., Schmidt, C., Beal, E., Hatzaras, I., Shenoy, R., IJzermans, J. N., van Gulik, T. M., Pawlik, T. M., Groot Koerkamp, B. 2017

Abstract

The aim of this study was to compare patients with PHC with lymph node metastases (LN+) who underwent a resection with patients who did not undergo resection because of locally advanced disease at exploratory laparotomy.Consecutive LN+ patients who underwent a resection for PHC in 12 centers were compared with patients who did not undergo resection because of locally advanced disease at exploratory laparotomy in 2 centers.In the resected cohort of 119 patients, the median overall survival (OS) was 19 months and the estimated 1-, 3- and 5-year OS was 69%, 27% and 13%, respectively. In the non-resected cohort of 113 patients, median OS was 12 months and the estimated 1-, 3- and 5-year OS was 49%, 7%, and 3%, respectively. OS was better in the resected LN+ cohort (p < 0.001). Positive resection margin (hazard ratio [HR]: 1.54; 95%CI: 0.97-2.45) and lymphovascular invasion (LVI) (HR: 1.71; 95%CI: 1.09-2.69) were independent poor prognostic factors in the resected cohort.Patients with PHC who underwent a resection for LN+ disease had better OS than patients who did not undergo resection because of locally advanced disease at exploratory laparotomy. LN+ PHC does not preclude 5-year survival after resection.

View details for DOI 10.1016/j.hpb.2017.04.014

View details for PubMedID 28549744