New to MyHealth?
Manage Your Care From Anywhere.
Access your health information from any device with MyHealth. You can message your clinic, view lab results, schedule an appointment, and pay your bill.
ALREADY HAVE AN ACCESS CODE?
DON'T HAVE AN ACCESS CODE?
NEED MORE DETAILS?
MyHealth for Mobile
Association of low numbers of CD206-positive cells with loss of ICC in the gastric body of patients with diabetic gastroparesis
Association of low numbers of CD206-positive cells with loss of ICC in the gastric body of patients with diabetic gastroparesis NEUROGASTROENTEROLOGY AND MOTILITY Bernard, C. E., Gibbons, S. J., Mann, I. S., FROSCHAUER, L., Parkman, H. P., Harbison, S., Abell, T. L., Snape, W. J., Hasler, W. L., McCallum, R. W., Sarosiek, I., Nguyen, L. A., Koch, K. L., Tonascia, J., Hamilton, F. A., Kendrick, M. L., Shen, K. R., Pasricha, P. J., Farrugia, G. 2014; 26 (9): 1275-1284Abstract
There is increasing evidence for specific cellular changes in the stomach of patients with diabetic (DG) and idiopathic (IG) gastroparesis. The most significant findings are loss of interstitial cells of Cajal (ICC), neuronal abnormalities, and an immune cellular infiltrate. Studies done in diabetic mice have shown a cytoprotective effect of CD206+ M2 macrophages. To quantify overall immune cellular infiltrate, identify macrophage populations, and quantify CD206+ and iNOS+ cells. To investigate associations between cellular phenotypes and ICC.Full thickness gastric body biopsies were obtained from non-diabetic controls (C), diabetic controls (DC), DG, and IG patients. Sections were labeled for CD45, CD206, Kit, iNOS, and putative human macrophage markers (HAM56, CD68, and EMR1). Immunoreactive cells were quantified from the circular muscle layer.Significantly fewer ICC were detected in DG and IG tissues, but there were no differences in the numbers of cells immunoreactive for other markers between patient groups. There was a significant correlation between the number of CD206+ cells and ICC in DG and DC patients, but not in C and IG and a significant correlation between iNOS+ cells and ICC in the DC group, but not the other groups. CD68 and HAM56 reliably labeled the same cell populations, but EMR1 labeled other cell types.Depletion of ICC and correlation with changes in CD206+ cell numbers in DC and DG patients suggests that in humans, like mice, CD206+ macrophages may play a cytoprotective role in diabetes. These findings may lead to novel therapeutic options, targeting alternatively activated macrophages.
View details for DOI 10.1111/nmo.12389
View details for Web of Science ID 000341625000007
View details for PubMedID 25041465
View details for PubMedCentralID PMC4149814