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Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging CANCER MEDICINE Farr, N., Wang, Y., D'Andrea, S., Gravelle, K. M., Hwang, J. H., Lee, D. 2017; 6 (5): 1082-1090

Abstract

The preclinical models of pancreatic adenocarcinoma provide an alternative means for determining the mechanisms of malignancy and possibilities for treatments, thus representing a resource of immense potential for cancer treatment in medicine. To evaluate different tumor models, quantifiable magnetic resonance imaging (MRI) techniques can play a significant role in identifying valuable in vivo biomarkers of tumor characteristics. We characterized three models of pancreatic cancer with multiparametric MRI techniques. Tumor stromal density of each tumor was measured using diffusion-weighted imaging and magnetization transfer (MT-MRI). Histologic measurement showed a similar trend with tumor fibrosis levels. Results indicated that MRI measurements can serve as a valuable tool in identifying and evaluating tumor characteristics.

View details for DOI 10.1002/cam4.1062

View details for Web of Science ID 000401330300020

View details for PubMedID 28390098

View details for PubMedCentralID PMC5430104