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Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacin STROKE Hoehn, B. D., Palmer, T. D., Steinberg, G. K. 2005; 36 (12): 2718-2724

Abstract

Newborn cells may participate in repair following ischemic brain injury, but their survival and function may be influenced by inflammation.We investigated the effects of indomethacin, a nonsteroidal antiinflammatory drug, on the fate of newborn cells following transient focal ischemia.Bromodeoxyuridine (BrdU)-labeled cells, including migrating neuroblasts, were observed in the neighboring striatum and overlying cortex 1 day poststroke. The density of BrdU+ cells labeled with doublecortin, nestin, glial fibrillary acidic protein, or NG2 was increased at 14 and 28 days. Indomethacin increased BrdU+ cells of all lineages and reduced microglial/monocyte activation.Indomethacin enhanced the accumulation of newborn cells following stroke.

View details for DOI 10.1161/01.STR.0000190020.30282.cc

View details for Web of Science ID 000233452400047

View details for PubMedID 16282546