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Tonsillectomy and Risk of Parkinson's Disease: A Danish Nationwide Population-Based Cohort Study MOVEMENT DISORDERS Svensson, E., Henderson, V. W., Szepligeti, S., Stokholm, M., Klug, T., Sorensen, H., Borghammer, P. 2018; 33 (2): 321–24

Abstract

We hypothesized that tonsillectomy modifies the risk of PD.To test the hypothesis in a nationwide population-based cohort study.We used Danish medical registries to construct a cohort of all patients in Denmark with an operation code of tonsillectomy 1980-2010 (n?=?195,169) and a matched age and sex general population comparison cohort (n?=?975,845). Patients were followed until PD diagnosis, death, censoring, or end of follow-up 30 November 2013. Using Cox regression, we computed hazard ratios for PD and corresponding 95% confidence intervals, adjusting for age and sex by study design, and potential confounders.We identified 100 and 568 patients diagnosed with PD among the tonsillectomy and general population comparison cohort, respectively, finding similar risks of PD (adjusted hazard ratio?=?0.95 [95% confidence interval: 0.76-1.19]; for?>?20 years' follow-up (adjusted hazard ratio?=?0.96 [95% confidence interval: 0.64-1.41]).Tonsillectomy is not associated with risk of PD, especially early-onset PD. © 2017 International Parkinson and Movement Disorder Society.

View details for PubMedID 29193401

View details for PubMedCentralID PMC5809198