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Hepatitis D Viremia Among Injection Drug Users in San Francisco JOURNAL OF INFECTIOUS DISEASES Mahale, P., Aka, P., Chen, X., Liu, P., Fram, B. J., Wang, A. S., Simenel, S., Tseng, F., Chen, S., Edlin, B. R., Glenn, J. S., O'Brien, T. R. 2018; 217 (12): 1902–6

Abstract

People who inject drugs (PWID) are commonly exposed to hepatitis B virus (HBV) and hepatitis D virus (HDV). We evaluated the prevalence of HDV viremia among hepatitis B surface antigen (HBsAg)-positive PWID (n = 73) using a new quantitative microarray antibody capture (Q-MAC) assay, HDV western blot, and HDV RNA. HDV Q-MAC performed well in this cohort: anti-HDV, 100% sensitivity and specificity; HDV viremia, 61.5% sensitivity and 100% specificity. Hepatitis D viremia was present in 35.6% of HBsAg-positive participants and was more common in those with resolved compared to chronic hepatitis C (5.1% vs 0.6%; adjusted odds ratio, 9.80; P < .0001).

View details for PubMedID 29800369

View details for PubMedCentralID PMC5972608