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FMS-like tyrosine kinase 3 in normal hematopoiesis and acute myeloid leukemia STEM CELLS Parcells, B. W., Ikeda, A. K., Simms-Waldrip, T., Moore, T. B., Sakamoto, K. M. 2006; 24 (5): 1174-1184

Abstract

Ligand-mediated activation of the FMS-like tyrosine kinase 3 (FLT3) receptor is important for normal proliferation of primitive hematopoietic cells. However, activating mutations in FLT3 induce ligand-independent downstream signaling that promotes oncogenesis through pathways involved in proliferation, differentiation, and survival. FLT3 mutations are identified as the most frequent genetic abnormality in acute myeloid leukemia and are also observed in other leukemias. Multiple small-molecule inhibitors are under development to target aberrant FLT3 activity that confers a poor prognosis in patients.

View details for DOI 10.1634/stemcells.2005-0519

View details for Web of Science ID 000240639200005

View details for PubMedID 16410383