Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
 

See our updated masking policy »

Stanford Health Care

Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) Era CANCER JOURNAL Moding, E. J., Mowery, Y. M., Kirsch, D. G. 2016; 22 (4): 267–73

Abstract

Stereotactic body radiation therapy (SBRT) utilizing a small number of high-dose radiation therapy fractions continues to expand in clinical application. Although many approaches have been proposed to radiosensitize tumors with conventional fractionation, how these radiosensitizers will translate to SBRT remains largely unknown. Here, we review our current understanding of how SBRT eradicates tumors, including the potential contributions of endothelial cell death and immune system activation. In addition, we identify several new opportunities for radiosensitization generated by the move toward high dose per fraction radiation therapy.

View details for PubMedID 27441746

View details for PubMedCentralID PMC4957656